Protein Details: Chloride channel CLIC-like protein 1

Protein ID

ICDB_Pro_0007

Protein Name

Chloride channel CLIC-like protein 1

Gene Name

clcc1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Length

609 amino acids

AlphaFoldDB

AF-A0A2R8Q3S9-F1-model_v4.pdb

Function

Seems to act as a chloride ion channel (By similarity). Plays a role in retina development .

Sequence

MKLSSSSSFGLCILVVFFCFVVIESAKIRIDGYNDEAWIDPYDMLNYDPTTKRMRKSTESESYQNVPTKRREFNSESCDVPKCPDEHECIKKLHILQKEFDEQKSKSTATLSKPVCLPVFKRFLSKLLKETSKLGLPDDGITAMHYDAEVKLSKQSLAEIQKLLNDEDGWTTGAMDEALSQILVQFKLHDYEAWKWRFEDTFHVDVDTVLKVSLIVLIIVAIICTQLWSVVSWFVQFRRMFAVSFFISLIWNWFHLYMLAFAEHKKNIVQVESFNAKCTGLKQLNWQDSLSEWYRRTWTLQDDPCKKYYEVLVVNPILLVPPTKAITITITNFITDPLKHIGEGISEFLRALLKDLPVTLQIPVLIIIILAILIFVYGSAQAAIHQVARFPRLGWRQEQPPPAVGQRQNPQLRAHEEPWEGGDARQPLPMRQDNRGNHVGNRGDQGFRDANAPENREEDRSMDIRQEFSTKRTPVETLQATGNTFPDDETDSQQRTQELDSGANVEEEVKVEEKEKKESFSVDNKEQKETKSPDRSEPITSEPPSSIDVKTVGADQGNEHLMCTKRKWAAQNGFKLQVILCEINSEASADLPEEEECFSFKHPVQETQS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in the hindbrain; swim bladder and the eye at 1 day post fertilization (dpf) with increased expression at 3 dpf (PubMed:30157172). At 3 dpf; most prominent expression in the retina; with strong expression in the ganglion cell layer; outer nuclear layer and the retinal pigmented epithelium (PubMed:30157172).

DOI ID

10.1038/nature12111; 10.1371/journal.pgen.1007504

RefSeq

XP_009294671.1